MARK1 anticorps

N° du produit ABIN6258271

Cet anticorps anti-MARK1 Polyclonal Lapin (ABIN6258271) détecte spécifiquement MARK1 dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour MARK1 anticorps (ABIN6258271)

Antigène: MARK1 (MAP/microtubule Affinity-Regulating Kinase 1 (MARK1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MARK1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-MARK1 anticorps

Specificité: MARK Antibody detects endogenous levels of total MARK

Réactivité croisée: Humain, Souris, Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide

Isotype: IgG

Information d'application

Indications d'application: WB 1:500~1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.Stable for 12 months from date of receipt

Date de péremption: 12 months

Détails sur MARK1

Antigène: MARK1 (MAP/microtubule Affinity-Regulating Kinase 1 (MARK1))

Autre désignation: MARK

Sujet:

Description: Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).

Gene: MARK1

Poids moléculaire: 89 kDa

ID gène: 4139

UniProt: Q9P0L2, Q7KZI7, P27448, Q96L34

Pathways: SARS-CoV-2 Protein Interactome, Phosphorylation & l'infection par le SRAS-CoV-2