PARP2 anticorps (Internal Region)

N° du produit ABIN6259061

Cet anticorps Lapin Polyclonal détecte spécifiquement PARP2 dans WB, ELISA, IF et ICC. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour PARP2 anticorps (Internal Region) (ABIN6259061)

Antigène: PARP2 (Poly (ADP-Ribose) Polymerase 2 (PARP2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PARP2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Détail du produit anti-PARP2 anticorps

Épitope: Internal Region

Specificité: PARP2 Antibody detects endogenous levels of total PARP2.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human PARP2, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur PARP2

Antigène: PARP2 (Poly (ADP-Ribose) Polymerase 2 (PARP2))

Autre désignation: PARP2

Sujet:

Description: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism (PubMed:10364231, PubMed:28190768). This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:10364231). Mediates serine ADP-ribosylation of target proteins following interaction with HPF1, HPF1 conferring serine specificity (PubMed:28190768).

Gene: PARP2

Poids moléculaire: 75 kDa

ID gène: 10038

UniProt: Q9UGN5

Pathways: Réparation de l'ADN