RAD51 Homolog B anticorps

N° du produit ABIN6259179

Détail du produit anti-RAD51 Homolog B anticorps

Antigène: RAD51 Homolog B (Rad51B)

Reactivité: Humain, Souris, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAD51 Homolog B est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: RAD51L1 Antibody detects endogenous levels of total RAD51L1

Réactivité croisée: Humain, Singe, Souris

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide

Isotype: IgG

Information d'application

Indications d'application: WB 1:500~1:1000 IHC: 1:50~1:200, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.Stable for 12 months from date of receipt

Date de péremption: 12 months

Détails sur RAD51 Homolog B

Antigène: RAD51 Homolog B (Rad51B)

Autre désignation: RAD51L1 (Rad51B Produits)

Synonymes: anticorps R51H2, anticorps RAD51L1, anticorps REC2, anticorps AI553500, anticorps Rad51l1, anticorps mREC2, anticorps ATRAD51B, anticorps T17D12.12, anticorps T17D12_12, anticorps RGD1560681, anticorps rad51l1, anticorps wu:fd07f04, anticorps zgc:56581, anticorps RAD51 paralog B, anticorps DNA repair (Rad51) family protein, anticorps Rad51 DNA recombinase 2, anticorps RAD51B, anticorps Rad51b, anticorps rad51b

Sujet:

Description: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway.

Gene: RAD51B

Poids moléculaire: 45 kDa

ID gène: 5890

UniProt: O15315

Pathways: Réparation de l'ADN