Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

AKAP8 anticorps (Internal Region)

AKAP8 Reactivité: Humain, Souris, Rat WB, IHC, ELISA, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6259857
  • Antigène Voir toutes AKAP8 Anticorps
    AKAP8 (A Kinase (PRKA) Anchor Protein 8 (AKAP8))
    Épitope
    • 15
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 50
    • 17
    • 14
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 45
    • 4
    • 1
    Lapin
    Clonalité
    • 48
    • 2
    Polyclonal
    Conjugué
    • 29
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp AKAP8 est non-conjugé
    Application
    • 26
    • 13
    • 13
    • 12
    • 10
    • 7
    • 7
    • 6
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    AKAP8 Antibody detects endogenous levels of total AKAP8.
    Homologie
    Bovine,Horse,Sheep,Dog
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human AKAP8, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product AKAP8 Anticorps primaire
  • Indications d'application
    WB: 1:500-1:3000, IHC: 1:50-1:200, IF/ICC: 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    AKAP8 (A Kinase (PRKA) Anchor Protein 8 (AKAP8))
    Autre désignation
    AKAP8 (AKAP8 Produits)
    Synonymes
    anticorps MGC108502, anticorps AKAP8, anticorps AKAP 95, anticorps AKAP-8, anticorps AKAP-95, anticorps AKAP95, anticorps 1200016A02Rik, anticorps AA673585, anticorps AU015639, anticorps Akap95, anticorps A-kinase anchoring protein 8, anticorps A kinase (PRKA) anchor protein 8, anticorps AKAP8, anticorps akap8, anticorps Akap8
    Sujet

    Description: Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) (PubMed:9473338). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation, the function appears to be independent from PKA-anchoring (PubMed:10601332, PubMed:10791967, PubMed:11964380). May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression (PubMed:14641107). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3, in this function may act redundantly with AKAP8L (PubMed:16980585). Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation (PubMed:22130794). May be involved in regulation of DNA replication by acting as scaffold for MCM2 (PubMed:12740381). Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation (PubMed:23995757). May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells (PubMed:16227597). May act as a carrier protein of GJA1 for its transport to the nucleus (PubMed:26880274). Seems to involved in modulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro and associates to GC-rich ribosomal RNA promoters (PubMed:26683827). Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation, the function probably implicates targeting of PKA to NFKB1 (By similarity).

    Gene: AKAP8

    Poids moléculaire
    76kDa
    ID gène
    10270
    UniProt
    O43823
    Pathways
    SARS-CoV-2 Protein Interactome
Vous êtes ici:
Support technique