AKAP8 anticorps (C-Term)

N° du produit ABIN7448405

L’anticorps anti-AKAP8 Polyclonal Lapin est utilisé pour la détection de AKAP8 dans des échantillons de Humain et Souris. Il a été validé pour IHC.

Aperçu rapide pour AKAP8 anticorps (C-Term) (ABIN7448405)

Antigène: AKAP8 (A Kinase (PRKA) Anchor Protein 8 (AKAP8))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AKAP8 est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-AKAP8 anticorps

Épitope: C-Term

Fonction: Rabbit anti-AKAP8/AKAP95 IHC Antibody, Affinity Purified

Homologie: Bovine,Gorilla,Chimpanzee

Purification: Affinity Purified

Immunogène: Between AA 642 and C-term

Isotype: IgG

Information d'application

Indications d'application: 1:100 - 1:500

Restrictions: For Research Use only

Stockage

Concentration: 100 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur AKAP8

Antigène: AKAP8 (A Kinase (PRKA) Anchor Protein 8 (AKAP8))

Autre désignation: AKAP8/AKAP95

Sujet: Background: AKAP8/AKAP95 has been characterized as a 95 kDa protein kinase A (PKA)-anchoring protein and regulatory subunit of PKA that functions to recruit the condensin complex for chromosome condensation during mitosis. A role in DNA replication has also been demonstrated through its interaction with the pre-replication complex component, MCM2 (mini-chromosome maintenance 2). Inhibition of AKAP8/AKAP95 association with MCM2 inhibits replication initiation and elongation in vitro. AKAP8/AKAP95 has also been shown to be involved in apoptosis. KAP8/AKAP95 associates with caspase 3 and serves as a carrier to transport caspase 3 from the cytoplasm to the nucleus to induce morphological changes in the nucleus.

ID gène: 10270

NCBI Accession: NP_005849

UniProt: O43823

Pathways: SARS-CoV-2 Protein Interactome