PRKAG2 anticorps (N-Term)

N° du produit ABIN6259920

Détail du produit anti-PRKAG2 anticorps

Antigène: PRKAG2 (Protein Kinase, AMP-Activated, gamma 2 Non-Catalytic Subunit (PRKAG2))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRKAG2 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: AMPKgamma2 Antibody detects endogenous levels of total AMPKgamma2.

Homologie: Pig,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human AMPKgamma2, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur PRKAG2

Antigène: PRKAG2 (Protein Kinase, AMP-Activated, gamma 2 Non-Catalytic Subunit (PRKAG2))

Autre désignation: PRKAG2 (PRKAG2 Produits)

Synonymes: anticorps MGC82938, anticorps PRKAG2, anticorps si:ch211-230l11.1, anticorps si:dkey-217f4.2, anticorps AAKG, anticorps AAKG2, anticorps CMH6, anticorps H91620p, anticorps WPWS, anticorps 2410051C13Rik, anticorps AI854673, anticorps protein kinase AMP-activated non-catalytic subunit gamma 2, anticorps protein kinase, AMP-activated, gamma 2 non-catalytic subunit L homeolog, anticorps 5'-AMP-activated protein kinase subunit gamma-2, anticorps protein kinase, AMP-activated, gamma 2 non-catalytic subunit b, anticorps protein kinase, AMP-activated, gamma 2 non-catalytic subunit, anticorps Prkag2, anticorps PRKAG2, anticorps prkag2.L, anticorps LOC504219, anticorps prkag2b, anticorps prkag2

Sujet:

Description: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton, probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.

Gene: PRKAG2

Poids moléculaire: 65kDa

ID gène: 51422

UniProt: Q9UGJ0

Pathways: AMPK Signaling, Cellular Glucan Metabolic Process, Ribonucleoside Biosynthetic Process, Regulation of Carbohydrate Metabolic Process, L'effet Warburg