CENPF anticorps (C-Term)

N° du produit ABIN6260754

Détail du produit anti-CENPF anticorps

Antigène: CENPF (Centromere Protein F (CENPF))

Épitope: C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CENPF est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Western Blotting (WB)

Specificité: CENPF Antibody detects endogenous levels of total CENPF.

Homologie: Pig

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human CENPF, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Date de péremption: 12 months

Détails sur CENPF

Antigène: CENPF (Centromere Protein F (CENPF))

Autre désignation: CENPF (CENPF Produits)

Synonymes: anticorps LOC100222985, anticorps 6530404A22Rik, anticorps AI325968, anticorps CENF, anticorps Lek1, anticorps PRO1779, anticorps mitosin, anticorps im:7140452, anticorps im:7144238, anticorps im:7154719, anticorps im:7156761, anticorps si:ch211-152h14.2, anticorps hcp-1, anticorps CMF1, anticorps centromere protein F, anticorps CENPF, anticorps Cenpf, anticorps cenpf

Sujet:

Description: Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cycle and in promoting continued mitosis in transformed, abnormally dividing neonatal cardiomyocytes. Interaction with RB directs embryonic stem cells toward a cardiac lineage. Involved in the regulation of DNA synthesis and hence cell cycle progression, via its C-terminus. Has a potential role regulating skeletal myogenesis and in cell differentiation in embryogenesis. Involved in dendritic cell regulation of T-cell immunity against chlamydia.

Gene: CENPF

Poids moléculaire: 367 kDa

ID gène: 1063

UniProt: P49454

Pathways: Chromatin Binding, M Phase, SARS-CoV-2 Protein Interactome, Phosphorylation & l'infection par le SRAS-CoV-2