SH3KBP1 anticorps (N-Term)

N° du produit ABIN6260842

Cet anticorps anti-SH3KBP1 est un anticorps Lapin Polyclonal détectant SH3KBP1 dans WB, IHC, ICC et IF. Adapté pour Humain, Rat et Souris.

Aperçu rapide pour SH3KBP1 anticorps (N-Term) (ABIN6260842)

Antigène: SH3KBP1 (SH3-Domain Kinase Binding Protein 1 (SH3KBP1))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SH3KBP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Détail du produit anti-SH3KBP1 anticorps

Épitope: N-Term

Specificité: CIN85 Antibody detects endogenous levels of total CIN85.

Homologie: Pig,Zebrafish,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human CIN85, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur SH3KBP1

Antigène: SH3KBP1 (SH3-Domain Kinase Binding Protein 1 (SH3KBP1))

Autre désignation: SH3KBP1

Sujet:

Description: Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion, promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration.

Gene: SH3KBP1

Poids moléculaire: 85 kDa

ID gène: 30011

UniProt: Q96B97

Pathways: EGFR Signaling Pathway, EGFR Downregulation