CISH anticorps (Internal Region)

N° du produit ABIN6260845

Cet anticorps anti-CISH est un anticorps Lapin Polyclonal détectant CISH dans WB et ELISA. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour CISH anticorps (Internal Region) (ABIN6260845)

Antigène: CISH (Cytokine Inducible SH2-Containing Protein (CISH))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CISH est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-CISH anticorps

Épitope: Internal Region

Specificité: CISH Antibody detects endogenous levels of total CISH.

Homologie: Bovine,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human CISH, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur CISH

Antigène: CISH (Cytokine Inducible SH2-Containing Protein (CISH))

Autre désignation: CISH

Sujet:

Description: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

Gene: CISH

Poids moléculaire: 29kDa

ID gène: 1154

UniProt: Q9NSE2

Pathways: Signalistation JAK/STAT, Response to Growth Hormone Stimulus