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Ephrin A1 anticorps (Internal Region)

EFNA1 Reactivité: Humain, Rat, Souris ELISA, WB, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6261448
  • Antigène Voir toutes Ephrin A1 (EFNA1) Anticorps
    Ephrin A1 (EFNA1)
    Épitope
    • 15
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 41
    • 21
    • 17
    • 1
    Humain, Rat, Souris
    Hôte
    • 46
    • 2
    • 1
    • 1
    Lapin
    Clonalité
    • 46
    • 4
    Polyclonal
    Conjugué
    • 23
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Ephrin A1 est non-conjugé
    Application
    • 22
    • 19
    • 13
    • 13
    • 12
    • 7
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    EFNA1 Antibody detects endogenous levels of total EFNA1.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human EFNA1, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product EFNA1 Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    Ephrin A1 (EFNA1)
    Autre désignation
    EFNA1 (EFNA1 Produits)
    Synonymes
    anticorps Xefrin-A1, anticorps b61, anticorps ecklg, anticorps efl1, anticorps efna1, anticorps efna1a, anticorps elfa-a, anticorps epha1, anticorps eplg1, anticorps lerk1, anticorps tnfaip4, anticorps xelf-a', anticorps xelfa, anticorps AI325262, anticorps B61, anticorps Efl1, anticorps Epl1, anticorps Eplg1, anticorps Lerk1, anticorps ECKLG, anticorps EFL1, anticorps EPLG1, anticorps LERK-1, anticorps LERK1, anticorps TNFAIP4, anticorps efna1b, anticorps MGC130661, anticorps ephrin-A1 S homeolog, anticorps ephrin-A1, anticorps ephrin A1, anticorps ephrin-A1b, anticorps ephrin-A1 L homeolog, anticorps efna1.S, anticorps efna1, anticorps EFNA1, anticorps efna1b, anticorps Efna1, anticorps efna1.L
    Sujet

    Description: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.

    Gene: EFNA1

    Poids moléculaire
    24kDa
    ID gène
    1942
    UniProt
    P20827
    Pathways
    Signalisation RTK
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