FGFR2 anticorps (C-Term)

N° du produit ABIN6261735

Détail du produit anti-FGFR2 anticorps

Antigène: FGFR2 (Fibroblast Growth Factor Receptor 2 (FGFR2))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FGFR2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Specificité: FGFR2 Antibody detects endogenous levels of total FGFR2.

Homologie: Pig,Zebrafish,Bovine,Horse,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human FGFR2, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000, IHC: 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur FGFR2

Antigène: FGFR2 (Fibroblast Growth Factor Receptor 2 (FGFR2))

Autre désignation: FGFR2 (FGFR2 Produits)

Synonymes: anticorps FGFR2, anticorps FGFR2IIIb, anticorps bek, anticorps bfr-1, anticorps cd332, anticorps cek3, anticorps cfd1, anticorps ect1, anticorps fgfr-2, anticorps jws, anticorps k-sam, anticorps kgfr, anticorps tk14, anticorps tk25, anticorps xfgfr2, anticorps DKFZp469H1521, anticorps BBDS, anticorps BEK, anticorps BFR-1, anticorps CD332, anticorps CEK3, anticorps CFD1, anticorps ECT1, anticorps JWS, anticorps K-SAM, anticorps KGFR, anticorps TK14, anticorps TK25, anticorps AU043015, anticorps AW556123, anticorps Bek, anticorps Fgfr-2, anticorps Fgfr-7, anticorps Fgfr7, anticorps KGFRTr, anticorps svs, anticorps FGF-R, anticorps fgfr72IIIb, anticorps FGFR, anticorps fc56c05, anticorps wu:fc56c05, anticorps fibroblast growth factor receptor 2, anticorps fibroblast growth factor receptor 2 L homeolog, anticorps FGFR2, anticorps LOC100084641, anticorps fgfr2, anticorps Fgfr2, anticorps fgfr2.L

Sujet:

Description: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.

Gene: FGFR2

Poids moléculaire: 92kDa

ID gène: 2263

UniProt: P21802

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Growth Factor Binding