HIPK3 anticorps (Internal Region)

N° du produit ABIN6262243

Détail du produit anti-HIPK3 anticorps

Antigène: HIPK3 (Homeodomain Interacting Protein Kinase 3 (HIPK3))

Épitope: Internal Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HIPK3 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: HIPK3 Antibody detects endogenous levels of total HIPK3.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human HIPK3, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur HIPK3

Antigène: HIPK3 (Homeodomain Interacting Protein Kinase 3 (HIPK3))

Autre désignation: HIPK3 (HIPK3 Produits)

Synonymes: anticorps HIPK3, anticorps pky, anticorps yak1, anticorps dyrk6, anticorps fist3, anticorps MGC145460, anticorps DYRK6, anticorps FIST3, anticorps PKY, anticorps YAK1, anticorps ANPK, anticorps homeodomain interacting protein kinase 3, anticorps homeodomain interacting protein kinase 3 L homeolog, anticorps HIPK3, anticorps hipk3.L, anticorps hipk3, anticorps Hipk3

Sujet:

Description: Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).

Gene: HIPK3

Poids moléculaire: 134 kDa

ID gène: 10114

UniProt: Q9H422