LCAT anticorps (C-Term)

N° du produit ABIN6262927

Détail du produit anti-LCAT anticorps

Antigène: LCAT (Lecithin-Cholesterol Acyltransferase (LCAT))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LCAT est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: LCAT Antibody detects endogenous levels of total LCAT.

Homologie: Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human LCAT, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur LCAT

Antigène: LCAT (Lecithin-Cholesterol Acyltransferase (LCAT))

Autre désignation: LCAT (LCAT Produits)

Synonymes: anticorps AI046659, anticorps D8Wsu61e, anticorps MGC82035, anticorps lcat, anticorps MGC88964, anticorps LCAT, anticorps lecithin-cholesterol acyltransferase, anticorps lecithin cholesterol acyltransferase, anticorps lecithin-cholesterol acyltransferase L homeolog, anticorps solute carrier family 12 member 4, anticorps fragile site, aphidicolin type, common, fra(13)(q13.2), anticorps LCAT, anticorps Lcat, anticorps lcat.L, anticorps lcat, anticorps SLC12A4, anticorps FRA13A

Sujet:

Description: Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs) (PubMed:10329423, PubMed:19065001, PubMed:26195816). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107). Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (PubMed:10722751).

Gene: LCAT

Poids moléculaire: 50 kDa

ID gène: 3931

UniProt: P04180

Pathways: Lipid Metabolism