MIB1 anticorps

N° du produit ABIN6263248

Cet anticorps anti-MIB1 Polyclonal Lapin (ABIN6263248) détecte spécifiquement MIB1 dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour MIB1 anticorps (ABIN6263248)

Antigène: MIB1 (Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MIB1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-MIB1 anticorps

Specificité: MIB1 Antibody detects endogenous levels of total MIB1

Réactivité croisée: Humain, Souris, Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human MIB1

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.Stable for 12 months from date of receipt

Date de péremption: 12 months

Détails sur MIB1

Antigène: MIB1 (Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1))

Autre désignation: MIB1

Sujet:

Description: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.

Gene: MIB1

Poids moléculaire: 110 kDa

ID gène: 57534

UniProt: Q86YT6

Pathways: SARS-CoV-2 Protein Interactome, Phosphorylation & l'infection par le SRAS-CoV-2