Mesothelin anticorps (AA 37-296)

N° du produit ABIN6290624

L’anticorps Lapin Polyclonal anti-Mesothelin a été validé pour WB, IHC et IF. Il convient pour détecter Mesothelin dans des échantillons de Humain et Rat.

Aperçu rapide pour Mesothelin anticorps (AA 37-296) (ABIN6290624)

Antigène: Mesothelin (MSLN)

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Mesothelin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-Mesothelin anticorps

Épitope: AA 37-296

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 37-296 of human MSLN (NP_001170826.1)

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:100

Commentaires:

Expressed in lung, Expressed at low levels in heart, placenta and kidney, Expressed in mesothelial cells, Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level)

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20C. Avoid freeze / thaw cycles.

Détails sur Mesothelin

Antigène: Mesothelin (MSLN)

Autre désignation: MSLN

Sujet: This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Poids moléculaire: 68.986 kDa

ID gène: 10232

UniProt: Q13421

Pathways: EGFR Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process