JUP anticorps (N-Term)

N° du produit ABIN6295501

Cet anticorps Souris Monoclonal détecte spécifiquement JUP dans WB, IF et IP. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour JUP anticorps (N-Term) (ABIN6295501)

Antigène: JUP (Junction Plakoglobin (JUP))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp JUP est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Détail du produit anti-JUP anticorps

Épitope: N-Term

Fonction: Mouse anti-Human/Mouse Gamma Catenin Antibody / Plakoglobin [Sodium Azide Free]

Specificité: Cell surface, cytoplasmic, cell junctions

Purification: Recombinant full length human gamma Catenin fused to maltose binding protein was used as the immunogen for the Plakoglobin antibody. The epitope has been found to be in the N-terminal region.

Immunogène: Recombinant full length human gamma Catenin fused to maltose binding protein was used as the immunogen for the Plakoglobin antibody. The epitope has been found to be in the N-terminal region.

Information d'application

Indications d'application: Immunofluorescence: 1-2 μg/mL
WB: 0.5-1 μg/mL
Immunoprecipitation: suitable

Restrictions: For Research Use only

Stockage

Buffer: In 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Détails sur JUP

Antigène: JUP (Junction Plakoglobin (JUP))

Autre désignation: Junction plakoglobin

Sujet:

Target Description: It recognizes a protein of 80-87 kDa, identified as gamma-Catenin or Plakoglobin. The catenins (alpha, beta, gamma and δ,) are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. alpha T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantly expressed in cardio-myocytes and in the peritubular myoid cells of the testis. alpha T-catenin binds to alpha E-catenin as well as to beta-catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for alpha-T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimer s disease (LOAD) as well as to dilated cardiomyopathy.

Gene Symbol: JUP///CTNNG///DP3

ID gène: 3728

UniProt: P14923

Pathways: Cell-Cell Junction Organization, Maintenance of Protein Location