beta-2 Microglobulin anticorps

N° du produit ABIN6297657

Cet anticorps anti-beta-2 Microglobulin est un anticorps Souris Monoclonal détectant beta-2 Microglobulin dans FACS et IF. Adapté pour Humain et Non-Human Primate.

Aperçu rapide pour beta-2 Microglobulin anticorps (ABIN6297657)

Antigène: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Reactivité: Humain, Non-Human Primate

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp beta-2 Microglobulin est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Détail du produit anti-beta-2 Microglobulin anticorps

Fonction: Mouse anti-Human/non-Human primates Beta-2 Microglobulin Antibody [Sodium Azide Free]

Specificité: Cytoplasmic

Purification: Soluble beta 2 microglobulin was used as the immunogen for the Beta-2 Microglobulin antibody.

Immunogène: Soluble beta 2 microglobulin was used as the immunogen for the Beta-2 Microglobulin antibody.

Information d'application

Indications d'application: Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: In 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Détails sur beta-2 Microglobulin

Antigène: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Autre désignation: Beta-2-microglobulin

Sujet:

Target Description: The antibody recognizes the hidden determinant of beta-2 microglobulin (i.e. binding to its determinant is available only when the chain is separated from the HLA heavy chain). Beta-2 microglobulin is a 12KDa protein with a pI of 5.6. Serum beta-2 microglobulin levels are a reflection of cell turnover. Levels rise with fever, inflammation, and infection. Increased serum levels are also seen in B-cell malignancies and in renal failure and may indicate a worse prognosis for patients with early-stage Hodgkin's lymphoma. In urine, increased levels are seen in proximal renal tubular disease as well as renal transplant rejection. Beta-2 microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumours and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy).

Gene Symbol: B2M///CDABP0092///HDCMA22P

ID gène: 567

UniProt: P61769

Pathways: TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process