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CD74 anticorps

CD74 Reactivité: Humain IHC Hôte: Souris Monoclonal unconjugated
N° du produit ABIN6297713
  • Antigène Voir toutes CD74 Anticorps
    CD74 (HLA-DR-gamma (CD74))
    Reactivité
    • 184
    • 65
    • 13
    • 11
    Humain
    Hôte
    • 123
    • 79
    • 4
    • 2
    Souris
    Clonalité
    • 139
    • 67
    • 2
    Monoclonal
    Conjugué
    • 70
    • 17
    • 16
    • 10
    • 10
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CD74 est non-conjugé
    Application
    • 126
    • 112
    • 80
    • 45
    • 37
    • 36
    • 31
    • 27
    • 18
    • 14
    • 13
    • 11
    • 10
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
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    • 1
    Immunohistochemistry (IHC)
    Fonction
    Mouse anti-Human CD74 Antibody Cocktail [IHC only]
    Specificité
    Cell surface and paranuclear globular
    Purification
    SU-DHL-4 lymphoma cells (LN-2) and recombinant full-length human protein (CLIP/813) were used as the immunogen for the CD74 antibody cocktail.
    Immunogène
    SU-DHL-4 lymphoma cells (LN-2) and recombinant full-length human protein (CLIP/813) were used as the immunogen for the CD74 antibody cocktail.
    Top Product
    Discover our top product CD74 Anticorps primaire
  • Indications d'application
    Prediluted format : incubate for 30 min at RT (2)
    Restrictions
    For Research Use only
  • Buffer
    Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
  • Antigène
    CD74 (HLA-DR-gamma (CD74))
    Autre désignation
    HLA class II histocompatibility antigen gamma chain (CD74 Produits)
    Synonymes
    anticorps DHLAG, anticorps HLADG, anticorps II, anticorps Ia-GAMMA, anticorps CLIP, anticorps Ii, anticorps INVG34, anticorps Iclp-1, anticorps iclp1, anticorps wu:fb11f09, anticorps wu:fb12a01, anticorps wu:fb13d06, anticorps wu:fk94e07, anticorps Iclp-2, anticorps cd74, anticorps iclp2, anticorps zgc:123161, anticorps CD74 molecule, anticorps CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated), anticorps CD74 molecule, major histocompatibility complex, class II invariant chain a, anticorps CD74 molecule, major histocompatibility complex, class II invariant chain b, anticorps CD74, anticorps Cd74, anticorps cd74a, anticorps cd74b
    Sujet

    Target Description: It recognizes a protein of ~35 kDa, identified as CD74/CLIP. It is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+).

    Gene Symbol: CD74///DHLAG

    ID gène
    296
    UniProt
    P04233
    Pathways
    Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints
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