CD74 anticorps

N° du produit ABIN6297729

Cet anticorps anti-CD74 est un anticorps Souris Monoclonal détectant CD74 dans FACS, WB et IF. Adapté pour Humain.

Aperçu rapide pour CD74 anticorps (ABIN6297729)

Antigène: CD74 (HLA-DR-gamma (CD74))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD74 est non-conjugé

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-CD74 anticorps

Fonction: Mouse anti-Human CD74 Antibody [Sodium Azide Free]

Specificité: Cell surface and paranuclear globular

Purification: The B lymphoblastoid cell line HFB1 was used as the immunogen for this antibody.

Immunogène: The B lymphoblastoid cell line HFB1 was used as the immunogen for this antibody.

Information d'application

Indications d'application: FACS: 0.5-1 μg/million cells
IF: 1-2 μg/mL
WB: 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: In 1X PBS ( pH 7.4), BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Détails sur CD74

Antigène: CD74 (HLA-DR-gamma (CD74))

Autre désignation: HLA class II histocompatibility antigen gamma chain

Sujet:

Target Description: This antibody recognizes proteins of 33, 35 and 41 kDa, which are identified as various isoforms of CD74. The CD74 antibody epitope is localized in the extracellular domain of CD74. CD74 is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. The CD74 Molecule plays a critical role in the presentation of peptides, by the MHC class II antigens, to CD4 positive lymphocytes. CD74 is expressed on MHC class II positive cells including B cells, a subset of activated T cells, monocytes, dendritic cells and by various types of carcinomas. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. CD74 antibody stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. CD74 antibody has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+).

Gene Symbol: CD74///DHLAG

ID gène: 972

UniProt: P04233

Pathways: Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints