CD74 anticorps
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- Antigène Voir toutes CD74 Anticorps
- CD74 (HLA-DR-gamma (CD74))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp CD74 est non-conjugé
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Application
- Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF)
- Fonction
- Mouse anti-Human CD74 Antibody [Sodium Azide Free]
- Specificité
- Cell surface and paranuclear globular
- Purification
- The B lymphoblastoid cell line HFB1 was used as the immunogen for this antibody.
- Immunogène
- The B lymphoblastoid cell line HFB1 was used as the immunogen for this antibody.
- Top Product
- Discover our top product CD74 Anticorps primaire
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- Indications d'application
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FACS: 0.5-1 μg/million cells
IF: 1-2 μg/mL
WB: 0.5-1 μg/mL - Restrictions
- For Research Use only
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- Buffer
- In 1X PBS ( pH 7.4), BSA free, sodium azide free
- Agent conservateur
- Azide free
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- Antigène
- CD74 (HLA-DR-gamma (CD74))
- Autre désignation
- HLA class II histocompatibility antigen gamma chain (CD74 Produits)
- Synonymes
- anticorps DHLAG, anticorps HLADG, anticorps II, anticorps Ia-GAMMA, anticorps CLIP, anticorps Ii, anticorps INVG34, anticorps Iclp-1, anticorps iclp1, anticorps wu:fb11f09, anticorps wu:fb12a01, anticorps wu:fb13d06, anticorps wu:fk94e07, anticorps Iclp-2, anticorps cd74, anticorps iclp2, anticorps zgc:123161, anticorps CD74 molecule, anticorps CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated), anticorps CD74 molecule, major histocompatibility complex, class II invariant chain a, anticorps CD74 molecule, major histocompatibility complex, class II invariant chain b, anticorps CD74, anticorps Cd74, anticorps cd74a, anticorps cd74b
- Sujet
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Target Description: This antibody recognizes proteins of 33, 35 and 41 kDa, which are identified as various isoforms of CD74. The CD74 antibody epitope is localized in the extracellular domain of CD74. CD74 is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. The CD74 Molecule plays a critical role in the presentation of peptides, by the MHC class II antigens, to CD4 positive lymphocytes. CD74 is expressed on MHC class II positive cells including B cells, a subset of activated T cells, monocytes, dendritic cells and by various types of carcinomas. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. CD74 antibody stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. CD74 antibody has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+).
Gene Symbol: CD74///DHLAG
- ID gène
- 972
- UniProt
- P04233
- Pathways
- Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints
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