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LAMP1 anticorps (PE)

LAMP1 Reactivité: Humain, Souris, Non-Human Primate FACS Hôte: Souris Monoclonal H4A3 PE
N° du produit ABIN638446
  • Antigène Voir toutes LAMP1 Anticorps
    LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))
    Reactivité
    • 105
    • 65
    • 37
    • 27
    • 8
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain, Souris, Non-Human Primate
    Hôte
    • 66
    • 56
    • 25
    • 1
    Souris
    Clonalité
    • 100
    • 48
    Monoclonal
    Conjugué
    • 53
    • 15
    • 15
    • 11
    • 9
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp LAMP1 est conjugé à/à la PE
    Application
    • 93
    • 74
    • 41
    • 34
    • 26
    • 25
    • 25
    • 16
    • 15
    • 13
    • 13
    • 7
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Specificité
    The mouse monoclonal antibody H4A3 recognizes an extracellular/luminal epitope of CD107a, an approximately 100-120 kDa glycoprotein expressed mainly on lysosomal, but also on the plasma membrane.
    Réactivité croisée (Details)
    Human, Non-Human Primates, Mouse
    Purification
    Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogène
    Human PBMC
    Clone
    H4A3
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product LAMP1 Anticorps primaire
  • Indications d'application
    Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests. Intracellular and extracellular staining.
    Commentaires

    The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

    Restrictions
    For Research Use only
  • Reconstitution
    No reconstitution is necessary.
    Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze.
    Avoid prolonged exposure to light.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Majer, Vlaskova, Krol, Kalina, Kubanek, Stolnaya, Dvorakova, Elleder, Sikora: "Danon disease: a focus on processing of the novel LAMP2 mutation and comments on the beneficial use of peripheral white blood cells in the diagnosis of LAMP2 deficiency." dans: Gene, Vol. 498, Issue 2, pp. 183-95, (2012) (PubMed).

    Mao, Tu, Liu, Qin, Zheng, Chan, Lam, Peiris, Lau: "Inhibition of human natural killer cell activity by influenza virions and hemagglutinin." dans: Journal of virology, Vol. 84, Issue 9, pp. 4148-57, (2010) (PubMed).

    Yu, Gallegos, Marches, Zurawski, Ramilo, García-Sastre, Banchereau, Palucka: "Broad influenza-specific CD8+ T-cell responses in humanized mice vaccinated with influenza virus vaccines." dans: Blood, Vol. 112, Issue 9, pp. 3671-8, (2008) (PubMed).

    Carlsten, Björkström, Norell, Bryceson, van Hall, Baumann, Hanson, Schedvins, Kiessling, Ljunggren, Malmberg: "DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells." dans: Cancer research, Vol. 67, Issue 3, pp. 1317-25, (2007) (PubMed).

    Tomescu, Chehimi, Maino, Montaner: "NK cell lysis of HIV-1-infected autologous CD4 primary T cells: requirement for IFN-mediated NK activation by plasmacytoid dendritic cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 4, pp. 2097-104, (2007) (PubMed).

    Marcenaro, Gallo, Martini, Santoro, Griffiths, Aricó, Moretta, Pende: "Analysis of natural killer-cell function in familial hemophagocytic lymphohistiocytosis (FHL): defective CD107a surface expression heralds Munc13-4 defect and discriminates between genetic subtypes of the disease." dans: Blood, Vol. 108, Issue 7, pp. 2316-23, (2006) (PubMed).

    Deetz, Hebbeler, Propp, Cairo, Tikhonov, Pauza: "Gamma interferon secretion by human Vgamma2Vdelta2 T cells after stimulation with antibody against the T-cell receptor plus the Toll-Like receptor 2 agonist Pam3Cys." dans: Infection and immunity, Vol. 74, Issue 8, pp. 4505-11, (2006) (PubMed).

    Furuta, Ikeda, Nakayama, Nakamura, Tanaka, Hamasaki, Himeno, Hamilton, August: "Expression of lysosome-associated membrane proteins in human colorectal neoplasms and inflammatory diseases." dans: The American journal of pathology, Vol. 159, Issue 2, pp. 449-55, (2001) (PubMed).

    Mane, Marzella, Bainton, Holt, Cha, Hildreth, August: "Purification and characterization of human lysosomal membrane glycoproteins." dans: Archives of biochemistry and biophysics, Vol. 268, Issue 1, pp. 360-78, (1989) (PubMed).

  • Antigène
    LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))
    Autre désignation
    CD107a (LAMP1 Produits)
    Synonymes
    anticorps CD107a, anticorps LAMPA, anticorps LGP120, anticorps AI196048, anticorps Lamp-1, anticorps LEP100, anticorps LAMP-1, anticorps LGP-A, anticorps Lgpa, anticorps Lysosome-associated membrane protein 1, anticorps cd107a, anticorps lamp-1, anticorps lamp1, anticorps lampa, anticorps lgp120, anticorps rexp76, anticorps lysosomal associated membrane protein 1, anticorps lysosomal-associated membrane protein 1, anticorps lysosomal-associated membrane protein 1 L homeolog, anticorps LAMP1, anticorps Lamp1, anticorps lamp1.L
    Sujet
    Lysosomal associated membrane protein 1,CD107a (lysosome-associated membrane protein-1, LAMP-1), together with LAMP-2, is a major constituent of lysosomal membrane, 1-2 % of total CD107a is found also on the plasma membrane. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes. Increased CD107a immunoreactivity is observed in neurones, and in glial cells surrounding senile plaques in Alzheimers disease cases and is localized mainly in medullary epithelial cells, single macrophages and lymphocytes in acute thymic involution. CD107a is a good marker of mast cell activation.,LAMP-1, LAMPA
    ID gène
    3916
    UniProt
    P11279
    Pathways
    Autophagy
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