Caspase 1 anticorps (C-Term)

N° du produit ABIN644993

L’anticorps anti-Caspase 1 Polyclonal Lapin est utilisé pour la détection de Caspase 1 dans des échantillons de Humain. Il a été validé pour WB et IHC (p).

Aperçu rapide pour Caspase 1 anticorps (C-Term) (ABIN644993)

Antigène: Caspase 1 (CASP1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Caspase 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-Caspase 1 anticorps

Épitope: C-Term

Fonction: Rabbit Anti-Human CASP1 (C-term)

Specificité: DS-PB-00372 recognizes an epitope within the C-terminal region (CT) of human Caspase-1, otherwise known as IL- 1Beta converting enzyme. Caspase-1 is an intracellular cysteine protease, identified as a mammalian homologue to C. elegans cell death gene (ced-3). Caspase-1 has been classified as an inflammatory, rather than apoptotic caspase, due to its essential role in the cleavage of the inactive precursors of the cytokines IL-1beta and IL-18, into their mature activated and secretable forms. This regulation of pro-inflammatory cytokines by Caspase-1 has made inhibitors of Caspase-1 a possible target for use as therapeutic drugs for the treatment of inflammatory diseases (1,2). This product detects a cleaved subunit band of approximately 21 kDa in human heart cell lysates (predicted precursor MWT 45.2kDa).

Attributs du produit: Phosphorylation/Apoptosis/Signal Transduction/Regulation

Purification: Purified

Immunogène: Antisera to human Caspase-1 (CT) were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.

Isotype: IgG

Information d'application

Indications d'application: Immunohistology - Paraffin, Western Blotting

Restrictions: For Research Use only

Stockage

Concentration: IgG concentration 1.0 mg/ml

Buffer: Phosphate buffered saline

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C

Détails sur Caspase 1

Antigène: Caspase 1 (CASP1)

Autre désignation: Caspase-1

Pathways: Apoptose, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity, Inflammasome