LDLRAP1 anticorps

N° du produit ABIN645905

L’anticorps anti-LDLRAP1 not_set Chèvre est utilisé pour la détection de LDLRAP1 dans des échantillons de Humain et Souris.

Aperçu rapide pour LDLRAP1 anticorps (ABIN645905)

Antigène: LDLRAP1 (Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1))

Reactivité: Humain, Souris

Hôte: Chèvre

Conjugué: Cet anticorp LDLRAP1 est non-conjugé

Application: Veuillez nous consulter SVP

Détail du produit anti-LDLRAP1 anticorps

Specificité: The goat Anti-ARH / LDL receptor antibody detects protein derived from human recombinant protein and human liver lysate at various concentrations.

Réactivité croisée: Humain, Souris

Attributs du produit: Goat Anti-ARH / LDL Receptor adaptor

Immunogène: Peptide with sequence C-DALKSAGRALIRS, from the N Terminus of the protein sequence according to NP_056442.1, was used as immunogen.

Isotype: IgG

Information d'application

Restrictions: For Research Use only

Stockage

Reconstitution: Supplied as 100µg of purified antibody. 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Please avoid freeze-thaw cycles.

Stock: -20 °C

Détails sur LDLRAP1

Antigène: LDLRAP1 (Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1))

Sujet: LDLRAP1 is an adaptor protein that interacts with the cytoplasmic tail of low density lipoprotein receptor , phospholipids, and components of the clathrin endocytic machinery. LDLR (low density lipoprotein receptor) is a member of the LDL receptor gene family, which includes LDLR, LRP, Megalin, VLDLR and apoER2. The LDL receptor family is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. The LDL receptor is a cell surface transmembrane protein that mediates the uptake of low density lipoprotein and its degradation in the lysosome, which provides cholesterol to cells. The cytoplasmic domain of the LDL receptor is necessary for the receptor to cluster in coated pits, which promotes the rapid endocytosis of bound LDL. Mutations in LDLR cause the autosomal dominant disease familial hypercholesterolemia (FH), which promotes premature coronary atherosclerosis.

NCBI Accession: NP_056442

Pathways: Lipid Metabolism