Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogène
This ARH (LDLRAP1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 277-306 amino acids from the C-terminal region of human ARH (LDLRAP1).
anticorps ARH, anticorps ARH1, anticorps ARH2, anticorps FHCB1, anticorps FHCB2, anticorps AA691260, anticorps Arh, anticorps Arh1, anticorps RGD1563417, anticorps arh, anticorps arh1, anticorps arh2, anticorps fhcb1, anticorps fhcb2, anticorps xptb, anticorps LDLRAP1, anticorps ldlrap1, anticorps sb:cb50, anticorps zgc:56121, anticorps zgc:158745, anticorps low density lipoprotein receptor adaptor protein 1, anticorps low density lipoprotein receptor adaptor protein 1 L homeolog, anticorps low density lipoprotein receptor adaptor protein 1 S homeolog, anticorps low density lipoprotein receptor adaptor protein 1a, anticorps low density lipoprotein receptor adaptor protein 1b, anticorps LDLRAP1, anticorps Ldlrap1, anticorps ldlrap1, anticorps ldlrap1.L, anticorps ldlrap1.S, anticorps ldlrap1a, anticorps ldlrap1b
Sujet
LDLRAP1 is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. This adapter protein is required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). LDLRAP1 may be required for LDL binding and internalization but not for receptor clustering in coated pits. This protein may facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits, and may also be involved in the internalization of other LDLR family members. Mutations in the LDLRAP1 gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia.