IDE anticorps

N° du produit ABIN6568815

Cet anticorps anti-IDE est un anticorps Lapin Polyclonal détectant IDE dans WB et IF. Adapté pour Humain et Souris.

Aperçu rapide pour IDE anticorps (ABIN6568815)

Antigène: IDE (Insulin-Degrading Enzyme (IDE))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IDE est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-IDE anticorps

Purification: Affinity purification

Immunogène: Recombinant protein of human IDE

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000 IF 1:10 - 1:100

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur IDE

Antigène: IDE (Insulin-Degrading Enzyme (IDE))

Autre désignation: IDE

Sujet:

Synonyms: Abeta-degrading protease,FLJ35968,Ide,IDE,Insulin protease,Insulin-degrading enzyme,Insulinase,Insulysin,OTTHUMP00000020097

Background: This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.

Poids moléculaire:

Observed_MW: 118kDa

Calculated_MW: 54kDa/117kDa

ID gène: 3416

UniProt: P14735

Pathways: SARS-CoV-2 Protein Interactome