Caspase 1 anticorps (AA 350-400)

N° du produit ABIN6579307

L’anticorps anti-Caspase 1 Polyclonal Lapin est utilisé pour la détection de Caspase 1 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, IHC, ELISA et IF.

Aperçu rapide pour Caspase 1 anticorps (AA 350-400) (ABIN6579307)

Antigène: Caspase 1 (CASP1)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Caspase 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-Caspase 1 anticorps

Épitope: AA 350-400

Fonction: Caspase-1 Antibody

Specificité: Caspase-1 Polyclonal Antibody detects endogenous levels of Caspase-1

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: The antiserum was produced against synthesized peptide derived from the C-terminal region of human CASP1. AA range:350-400

Isotype: IgG

Information d'application

Indications d'application: IF 1:50-200 WB 1:500-2000, IHC 1:50-300, ELISA 1:10000-20000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur Caspase 1

Antigène: Caspase 1 (CASP1)

Autre désignation: CASP1

Sujet:

Synonyms: caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)

Background: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme.This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012],

Gene Name: CASP1 IL1BC IL1BCE

Protein Name: Caspase1

Poids moléculaire: 35 kDa

ID gène: 834

OMIM: 147678

UniProt: P29466

Pathways: Apoptose, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity, Inflammasome