MMP2 anticorps

N° du produit ABIN659015

Il existe 4+ publications pour ce produit. L’anticorps anti-MMP2 Monoclonal Souris est utilisé pour la détection de MMP2 dans des échantillons de Humain. Il a été validé pour WB et IHC (p).

Aperçu rapide pour MMP2 anticorps (ABIN659015)

Antigène: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MMP2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 6E3F8

Détail du produit anti-MMP2 anticorps

Purification: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Immunogène: This MMP2 antibody is generated from mouse immunized with MMP2 recombinant protein.

Isotype: IgG2b kappa

Information d'application

Indications d'application: WB: 1:200~1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Mouse monoclonal antibody supplied in crude ascites with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze-thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-MMP2 (ABIN659015)

Zhou, Wang, Ban, Zeng, Zhu, Li, Guan, Li: "DHRS2 inhibits cell growth and motility in esophageal squamous cell carcinoma." dans: Oncogene, Vol. 37, Issue 8, pp. 1086-1094, (2018) (PubMed).

Li, Zhou, Yang, Zhou, Tan, Yuan, Song, Chen, Zhang: "The CD147/MMP-2 signaling pathway may regulate early stage cardiac remodelling in spontaneously hypertensive rats." dans: Clinical and experimental pharmacology & physiology, Vol. 43, Issue 11, pp. 1125-1133, (2017) (PubMed).

Huang, Chiu, Chou, Su, Chen, Chai, Huang, Huang, Yuan, Lee: "Association of MMP-2 and MMP-9 expression with recurrences in primary spontaneous pneumothorax." dans: The Kaohsiung journal of medical sciences, Vol. 33, Issue 1, pp. 17-23, (2017) (PubMed).

Wang, Cao, Huang, Ke, Luo, Lin, Wang, Zhang, Wang: "EFEMP1 promotes the migration and invasion of osteosarcoma via MMP-2 with induction by AEG-1 via NF-κB signaling pathway." dans: Oncotarget, Vol. 6, Issue 16, pp. 14191-208, (2016) (PubMed).

Détails sur MMP2

Antigène: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Autre désignation: MMP2

Sujet: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire: 73882

ID gène: 4313

NCBI Accession: NP_001121363, NP_004521

UniProt: P08253

Pathways: Activation of Innate immune Response