Aurora Kinase B anticorps (AA 89-251)

N° du produit ABIN6654235

L’anticorps Lapin Monoclonal anti-Aurora Kinase B a été validé pour IHC (p). Il convient pour détecter Aurora Kinase B dans des échantillons de Humain.

Aperçu rapide pour Aurora Kinase B anticorps (AA 89-251) (ABIN6654235)

Antigène: Aurora Kinase B (AURKB)

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Aurora Kinase B est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: ARRK2-2R

Détail du produit anti-Aurora Kinase B anticorps

Épitope: AA 89-251

Purification: Purified

Pureté: Protein A affinity

Immunogène: A portion of amino acids 89-251 was used as the immunogen for this recombinant AURKB antibody.

Isotype: IgG kappa

Information d'application

Indications d'application: Optimal dilution of the recombinant AURKB antibody should be determined by the researcher.\. IHC (FFPE): 1-2 μg/mL for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1)

Restrictions: For Research Use only

Stockage

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the recombinant AURKB antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Détails sur Aurora Kinase B

Antigène: Aurora Kinase B (AURKB)

Autre désignation: Aurora B / AURKB

Sujet: Recognizes a protein of 39 kDa, which is identified as Aurora B. The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.

Pathways: TCR Signaling, Cycle Cellulaire, Maintenance of Protein Location, Hepatitis C, Toll-Like Receptors Cascades