BAP1 anticorps (AA 191-326)

N° du produit ABIN6654721

L’anticorps Souris Monoclonal anti-BAP1 a été validé pour IHC (p). Il convient pour détecter BAP1 dans des échantillons de Humain.

Aperçu rapide pour BAP1 anticorps (AA 191-326) (ABIN6654721)

Antigène: BAP1 (BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BAP1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: BAP1-2431

Détail du produit anti-BAP1 anticorps

Épitope: AA 191-326

Purification: Purified

Pureté: Protein G affinity chromatography

Immunogène: A portion of amino acids 191-326 from the human protein was used as the immunogen for the BAP1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the BAP1 antibody to be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. IHC (FFPE): 1-2 μg/mL for 30 min at RT,Prediluted IHC only format : incubate for 30 min at RT

Restrictions: For Research Use only

Stockage

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the BAP1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Détails sur BAP1

Antigène: BAP1 (BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1))

Autre désignation: BAP1 / BRCA1-Associated Protein 1

Sujet: The BAP1 gene belongs to the ubiquitin C-terminal hydrolase subfamily of de-ubiquitination enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germ line mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, Uveal melanoma and cutaneous melanoma.