PML anticorps

N° du produit ABIN6655213

N° du produit (Fournisseur): 600-401-x44

L’anticorps Lapin Polyclonal anti-PML a été validé pour WB et ELISA. Il convient pour détecter PML dans des échantillons de Humain.

Aperçu rapide pour PML anticorps (ABIN6655213)

Antigène: PML (Promyelocytic Leukemia (PML))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PML est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-PML anticorps

N° du produit (Fournisseur): 600-401-x44

Fournisseur: Rockland

Fonction: PML Antibody

Réactivité croisée (Details): Cross reactivity with other species was not tested.

Purification: Anti-PML Antibody was purified by affinity purification.

Stérilité: Sterile filtered

Immunogène: Anti-PML Antibody was produced in rabbits by repeated immunizations with three different synthetic peptides from human PML.

Isotype: IgG

Information d'application

Indications d'application:

ELISA_Dilution: 1:100 - 1:200

Western_Blot_Dilution: 1:750

Commentaires:

Anti-PML Antibody is tested for ELISA and Western Blots. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 115 and 60 kDa in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2

Stabilizer: None

Preservative: 0.05 % (w/v) Sodium Azide and 0.05 % ProClin 300

Agent conservateur: ProClin, Sodium azide

Précaution d'utilisation: This product contains Sodium azide and ProClin: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Date de péremption: 12 months

Détails sur PML

Antigène: PML (Promyelocytic Leukemia (PML))

Autre désignation: PML

Sujet:

Synonyms: Protein PML Promyelocytic leukemia protein, RING finger protein 71, Tripartite motif-containing protein 19, MYL, PP8675, RNF71, TRIM19

Background: PML is a transcription factor and tumor supressor which belongs to the tripartite motif (TRIM) family. This motif contains three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. PML regulates the response of p53 to oncogenic signals. It is often involved in a chromosomal translocation between chromosomes 15 and 17 which results in a PML/RARalpha fusion protein and is associated with most cases of acute promyelocytic leukemia. Anti-PML Antibody is ideal for research in Gene Expression, Cell Cycle Control and Cancer.

Gene Name: PML

ID gène: 5371

NCBI Accession: NP_002666

UniProt: P29590

Pathways: Signalisation p53, Retinoic Acid Receptor Signaling Pathway, Maintenance of Protein Location, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus