KDM1B anticorps (Internal Region, N-Term)

N° du produit ABIN6655594

Détail du produit anti-KDM1B anticorps

Antigène: KDM1B (Lysine (K)-Specific Demethylase 1B (KDM1B))

Épitope: Internal Region, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KDM1B est non-conjugé

Application: ELISA

Réactivité croisée (Details): Cross reactivity with KDM1B from other species not tested.

Purification: Anti-KDM1B Antibody is monospecific antiserum processed by delipidation and defibrination followed by sterile filtration.

Immunogène:

Immunogen: Anti-KDM1B Antibody was produced in rabbits by repeated immunizations with two different synthetic peptides containing a sequence from the N-terminus and internal region of the human KDM1B protein.

Immunogen Type: Peptide

Information d'application

Indications d'application:

Application Note: Anti-KDM1B Antibody is suitable for ELISA. Specific conditions for reactivity should be optimized by the end user.

ELISA Dilution: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

0.01 % (w/v) Sodium Azide

Stabilizer: None

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: RT,4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Détails sur KDM1B

Antigène: KDM1B (Lysine (K)-Specific Demethylase 1B (KDM1B))

Autre désignation: KDM1B (KDM1B Produits)

Synonymes: anticorps AOF1, anticorps C6orf193, anticorps LSD2, anticorps bA204B7.3, anticorps dJ298J15.2, anticorps 4632428N09Rik, anticorps AI482520, anticorps Aof1, anticorps lysine demethylase 1B, anticorps lysine-specific histone demethylase 1B, anticorps lysine (K)-specific demethylase 1B, anticorps KDM1B, anticorps LOC577549, anticorps kdm1b, anticorps Kdm1b

Sujet:

Synonyms: Lysine-specific histone demethylase 1B, Flavin-containing amine oxidase domain-containing protein 1, Lysine-specific histone demethylase 2, AOF1, C6orf193, LSD2

Background: KDM1B is a histone demethylase that demethylates lysine 4 of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. KDM1B is able to demethylate both mono- and di-methylated lysine 4 of histone H3, but has no effect on tri-methylated lysine 4, mono-, di- or tri-methylated lysine 9, mono-, di- or tri-methylated lysine 27, mono-, di- or tri-methylated lysine 36 of histone H3, or on mono-, di- or tri-methylated lysine 20 of histone H4. KDM1B is also required for de novo DNA methylation of a subset of imprinted genes during oogenesis. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Anti-KDM1B is ideal for research in Epigenetics and Gene Expression.

Gene Name: KDM1B

ID gène: 221656

NCBI Accession: NP_694587

UniProt: Q8NB78

Pathways: L'effet Warburg