Caspase 1 anticorps (C-Term)

N° du produit ABIN6655699

N° du produit (Fournisseur): 200-301-h62

L’anticorps Souris Monoclonal anti-Caspase 1 a été validé pour WB, IHC et IF. Il convient pour détecter Caspase 1 dans des échantillons de Humain.

Aperçu rapide pour Caspase 1 anticorps (C-Term) (ABIN6655699)

Antigène: Caspase 1 (CASP1)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Caspase 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Clone: 14F468

Détail du produit anti-Caspase 1 anticorps

Épitope: C-Term

N° du produit (Fournisseur): 200-301-h62

Fournisseur: Rockland

Fonction: Caspase-1 Antibody

Réactivité croisée (Details): A BLAST analysis was used to suggest cross-reactivity with Anti-Caspase-1 from human and mouse based on 100 % homology with the immunizing sequence.

Purification: Anti-Caspase-1 Antibody was purified by Protein G chromatography.

Immunogène: Caspase-1 Antibody was produced in mice by repeated immunizations with a synthetic peptide corresponding to amino acids near the c-terminus of the immunogen, human Caspase-1.

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Immunohistochemistry_Dilution: 1:100 - 1:500

Western_Blot_Dilution: 0.5-2 μg/mL

Commentaires:

Anti-Caspase-1 antibody has been tested in IHC-F, IHC-P, IF, and WB. Expect a band approximately 46kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Optional[Buffer]: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 ,0.05 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Date de péremption: 12 months

Détails sur Caspase 1

Antigène: Caspase 1 (CASP1)

Autre désignation: Caspase-1

Sujet:

Synonyms: IL1BC, IL1BCE, Caspase-1, CASP-1, 3.4.22.36, Interleukin-1 beta convertase, IL-1BC, Interleukin-1 beta-converting enzyme, ICE, IL-1 beta-converting enzyme, p45, Caspase-1 subunit p20, Caspase-1 subunit p10

Background: Anti-Caspase-1 detects human Caspase. Caspase proteins are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis. The precursor form of all caspase proteins is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into tetramer to form the active enzyme. Caspase-1 (ICE, IL-1b converting enzyme) is similar to the cell death gene CED-3 of Caenorhabditilis elegans and regulates multiple proinflammatory cytokines, including interleukin-1b and interferon-gamma-inducing factor. Anti-Caspase-1 antibody is ideal for investigators involved in apoptosis research.

Gene Name: CASP1

ID gène: 834

NCBI Accession: NP_001214

UniProt: P29466

Pathways: Apoptose, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity, Inflammasome