RAGE anticorps (Internal Region)

N° du produit ABIN6657517

N° du produit (Fournisseur): 600-401-p67

L’anticorps Lapin Polyclonal anti-RAGE a été validé pour WB et IHC. Il convient pour détecter RAGE dans des échantillons de Humain. Il y a 1 publication disponible.

Aperçu rapide pour RAGE anticorps (Internal Region) (ABIN6657517)

Antigène: RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAGE est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-RAGE anticorps

Épitope: Internal Region

N° du produit (Fournisseur): 600-401-p67

Fournisseur: Rockland

Fonction: AGER/RAGE Antibody

Réactivité croisée (Details): Anti-RAGE antibody is directed against human RAGE protein.

Purification: The product was affinity purified from monospecific antiserum by immunoaffinity purification.

Immunogène: AGER/RAGE affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region of human RAGE.

Isotype: IgG

Information d'application

Indications d'application:

Immunohistochemistry_Dilution: 1:100-1:500

Western_Blot_Dilution: 0.5 μg/mL

Commentaires:

Suggested Applications: IF
Anti-RAGE is tested for Immunohistochemistry-P, -F, and Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately ~42.8 kDa corresponding to the appropriate cell lysate or extract.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution:

Reconstitution_Buffer: Restore with deionized water (or equivalent)

Reconstitution_Volume: 250 μL

Buffer:

Buffer: 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide

Stabilizer: 5 mg BSA

Preservative: 0.05 mg Thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at 4° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Date de péremption: 12 months

Références pour anticorps anti-RAGE (ABIN6657517)

Bochi, Ferreira, Del Bianco, Pinto, Rodrigues, Trevisani, Furukawa, Bispo, da Silva, Velosa, Nakandakare, Machado, Teodoro, Passarelli, Catanozi: "Aerobic Exercise Training Reduces Atherogenesis Induced by Low-Sodium Diet in LDL Receptor Knockout Mice." dans: Antioxidants (Basel, Switzerland), Vol. 11, Issue 10, (2022) (PubMed).

Détails sur RAGE

Antigène: RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

Autre désignation: AGER/RAGE

Sujet:

Synonyms: Receptor for advanced glycosylation end products,

Background: The receptor for advanced glycation end products (RAGE) is a multi-ligand member of the immunoglobulin superfamily of cell surface molecules. It interacts with distinct molecules implicated in homeostasis, development and inflammation, and certain diseases such as diabetes and Alzheimer's disease. RAGE is also a central cell surface receptor for amphoterin and EN-RAGE. RAGE is associated with sustained NF-kappaB activation in the diabetic microenvironment and has a central role in sensory neuronal dysfunction. Moreover, RAGE propagates cellular dysfunction in several inflammatory disorders and diabetes, and it also functions as an endothelial adhesion receptor promoting leukocyte recruitment. This antibody is suitable for researchers interested in neuroscience research.

Gene Name: AGER

ID gène: 177

NCBI Accession: NP_001127

UniProt: Q15109

Pathways: Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, S100 Proteins