TFAM anticorps (C-Term)

N° du produit ABIN6657693

N° du produit (Fournisseur): 100-401-x30

Cet anticorps Lapin Polyclonal détecte spécifiquement TFAM dans WB et ELISA. Il présente une réactivité envers Souris.

Aperçu rapide pour TFAM anticorps (C-Term) (ABIN6657693)

Antigène: TFAM (Transcription Factor A, Mitochondrial (TFAM))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TFAM est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-TFAM anticorps

Épitope: C-Term

N° du produit (Fournisseur): 100-401-x30

Fournisseur: Rockland

Fonction: TFAM Antibody

Purification: Anti-TFAM Antibody is a prepared sterile filtered neat serum.

Stérilité: Sterile filtered

Immunogène: Anti-TFAM Antibody was produced in rabbits by repeated immunizations with a native recombinant mouse TFAM protein with c-terminal 6-his tag.

Isotype: IgG

Information d'application

Indications d'application:

ELISA_Dilution: 1:20,000

Western_Blot_Dilution: 1:2000

Commentaires:

Anti-TFAM Antibody has been tested in Western Blots and is specific for the ~24 kDa TFAM protein. Specific conditions for reactivity should be optimized by the end user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: None

Stabilizer: None

Preservative: None

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: Store vial at -20° C prior to opening in undiluted aliquots. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.

Date de péremption: 12 months

Détails sur TFAM

Antigène: TFAM (Transcription Factor A, Mitochondrial (TFAM))

Autre désignation: TFAM

Sujet:

Synonyms: Transciption factor A mitochondrial, mtTFA, Testis-specific high mobility group protein, TS-HMG

Background: Mitochondrial Transcription Factor A (TFAM) is a key activator of mitochondrial (mt) DNA transcription as well as a participant in mitochondrial genome replication. mtDNA is highly susceptible to oxidative stress leading to mitochondrial dysfunction. Overexpression of TFAM has been implicated in the amelioration of age dependent impairment of brain functions through the prevention of oxidative stress and mitochondrial dysfunction in microglia. More recently, TFAM overexpression has been shown to potentially reduce oxidative stress in motor neurons and delay onset of amyotrophic lateral sclerosis (ALS) in ALS model mice. TFAM Antibody is ideal for researchers interested in neuroscience research.

Gene Name: TFAM

ID gène: 21780

NCBI Accession: NP_033386

UniProt: P40630

Pathways: Chromatin Binding