SNCA anticorps (pSer129)

N° du produit ABIN6658101

N° du produit (Fournisseur): 612-401-c70

Cet anticorps Lapin Polyclonal détecte spécifiquement SNCA dans WB et ELISA. Il présente une réactivité envers Rat.

Aperçu rapide pour SNCA anticorps (pSer129) (ABIN6658101)

Antigène: SNCA (Synuclein, alpha (SNCA))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SNCA est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-SNCA anticorps

Épitope: pSer129

N° du produit (Fournisseur): 612-401-c70

Fournisseur: Rockland

Fonction: Alpha Synuclein phospho S129 Antibody

Réactivité croisée (Details): Anti-Alpha Synuclein pS129 Antibody is directed against rat Alpha-synuclein phosphorylated at S129.

Purification: The antibody was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities.

Immunogène: Anti-Alpha Synuclein pS129 Antibody was produced by repeated immunizations with a synthetic phospho peptide corresponding to amino acid residues surrounding Ser129.

Isotype: IgG

Information d'application

Indications d'application:

ELISA_Dilution: 1:10,000

Western_Blot_Dilution: 1:1000

Commentaires:

Alpha Synuclein pS129 antibody is tested for use in ELISA, Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 15 kDa in size corresponding to the alpha synuclein protein phosphorylated at Ser129 in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Date de péremption: 12 months

Détails sur SNCA

Antigène: SNCA (Synuclein, alpha (SNCA))

Autre désignation: Alpha Synuclein

Sujet:

Synonyms: Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor

Background: Alpha Synuclein pS129 Antibody detects Alpha-synuclein phosphorylated at S129. Alpha-synuclein is a presynaptic neuronal protein that is thought to be involved in the formation of SNARE complexes. Most significantly, aggregated alpha-synuclein is one of the major components found in the Lewy bodies that occur in Parkinson's disease (PD) and other neurodegenerative disorders. Mutation of the alpha-synuclein gene is associated with familial forms of PD. Recent evidence suggests that phosphorylation of alpha-synuclein at Ser129 plays a role in the formation of inclusions in PD. Anti-Alpha-synuclein pS129 antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.

Gene Name: SNCA

ID gène: 29219

NCBI Accession: NP_062042

UniProt: P37377

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity