TANK anticorps (AA 151-260) (Cy7)

N° du produit ABIN685363

Cet anticorps Lapin Polyclonal détecte spécifiquement TANK dans IF (cc) et IF (p). Il présente une réactivité envers Humain.

Aperçu rapide pour TANK anticorps (AA 151-260) (Cy7) (ABIN685363)

Antigène: TANK (TRAF Family Member-Associated NFKB Activator (TANK))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TANK est conjugé à/à la Cy7

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-TANK anticorps (Cy7)

Épitope: AA 151-260

Homologie: Human,Mouse,Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human TANK

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur TANK

Antigène: TANK (TRAF Family Member-Associated NFKB Activator (TANK))

Autre désignation: TANK

Sujet:

Synonyms: I TRAF, ITRAF, TRAF family member associated NF KAPPA B activator, TRAF family member associated NFKB activator, TRAF interacting protein, TRAF interacting protein TANK isoform a, I-TRAF, Tank, TANK_HUMAN, TRAF family member-associated NF-kappa-B activator, TRAF-interacting protein, TRAF interacting protein TANK isoform b, TRAF2.

Background: TANK was initially identified as a novel TRAF-interacting protein that regulated TRAF-mediated signal transduction. Specifically, ligand binding by surface receptors in the tumor necrosis factor (TNF) receptor and Toll/interleukin-1 (IL-1) receptor families lead to the formation of a TRAF/TANK complex that mediates the activation of the transcription factor NF-kappaB. TANK is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, this protein can block TRAF2 binding to LMP1, the Epstein Barr virus transforming protein, and inhibit LMP1-mediated NF kappa B activation.

ID gène: 10010

Pathways: Signalisation p53, Signalisation TLR, Activation of Innate immune Response