AKAP12 anticorps (AA 701-900)

N° du produit ABIN685732

Détail du produit anti-AKAP12 anticorps

Antigène: AKAP12 (A Kinase (PRKA) Anchor Protein 12 (AKAP12))

Épitope: AA 701-900

Reactivité: Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AKAP12 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Souris, Rat

Homologie: Human,Dog

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human of human AKAP12

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur AKAP12

Antigène: AKAP12 (A Kinase (PRKA) Anchor Protein 12 (AKAP12))

Autre désignation: AKAP12/Gravin (AKAP12 Produits)

Synonymes: anticorps akap12, anticorps cb27, anticorps esr1, anticorps fb72g12, anticorps id:ibd1202, anticorps sb:cb27, anticorps si:ch73-192g21.1, anticorps wu:fb72g12, anticorps wu:fc21c03, anticorps AKAP12, anticorps AI317366, anticorps SSeCKS, anticorps Srcs5, anticorps Tsga12, anticorps AKAP12A, anticorps AKAP12B, anticorps AKAP12G, anticorps AKAP250, anticorps A kinase (PRKA) anchor protein 12b, anticorps A-kinase anchoring protein 12, anticorps A kinase (PRKA) anchor protein (gravin) 12, anticorps akap12b, anticorps AKAP12, anticorps Akap12

Sujet:

Synonyms: A kinase PRKA anchor protein gravin 12, A kinase Anchor Protein 12, A kinase anchor protein 250 kDa, AKAP 12, AKAP 250, AKAP250, DKFZp686M0430, DKFZp686O0331, Gercelin, Gravin, Kinase scaffold protein gravin, Myasthenia gravis autoantigen gravin, Srcs5, SSeCKS, Tsga12.

Background: Gravin (also known as A Kinase Anchor Protein 12, AKAP12) was cloned from a cDNA expression library screened with serum, from a myasthenia gravis patient. to Gravin were found in 22 out of 72 myasthemia gravis patients and absent in sera of normal individuals. This protein is a myristoylated high molecular weight cytoplasmic protein expressed in endothelial cells, cultured fibroblasts and osteosarcoma cells and highly expressed in the brain. Gravin can bind kinases like PKA and PKC by different domains of the protein and can localize these kinases to specific domains in the cell. Upon differentiation of NT2 cells to neurons (NT2 N), Gravin expression is up regulated and enriched at the inner peripheral cortex in close proximity to the plasma membrane. In differentiated cells, gravin is co-localized with PKCbII, PKCa and PKA. Decreased binding of PKCa to gravin was found after activation of PKC.

ID gène: 9590

Pathways: cAMP Metabolic Process