IFI16 anticorps (AA 201-350) (Biotin)

N° du produit ABIN687039

Détail du produit anti-IFI16 anticorps (Biotin)

Antigène: IFI16 (Interferon, gamma-Inducible Protein 16 (IFI16))

Épitope: AA 201-350

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IFI16 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human IFI16

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur IFI16

Antigène: IFI16 (Interferon, gamma-Inducible Protein 16 (IFI16))

Autre désignation: I16/MNDA (IFI16 Produits)

Synonymes: anticorps IFNGIP1, anticorps PYHIN2, anticorps IFI16, anticorps Ifitm3l, anticorps Ifitml, anticorps interferon gamma inducible protein 16, anticorps interferon induced transmembrane protein 2, anticorps myeloid cell nuclear differentiation antigen-like protein, anticorps interferon-activable protein 203, anticorps IFI16, anticorps Ifitm2, anticorps LOC100156073, anticorps LOC488622, anticorps Ifi16

Sujet:

Synonyms: Gamma-interferon-inducible protein i16, Interferon-inducible myeloid dferentiation transcriptional activator, A730048F03, D3, D3cDNA, i-d3, I16, I16B, I204, I205, i205a, i205b, NGIP1, MGC9466, Mnda, p204, PYHIN2.

Background: Interferon (IFN) Inducible 16 (IFI16) protein belongs to a family of HIN 200 human and mouse proteins. IFI16 is a nuclear protein comtaining regulatory domains such as DNA binding domain, transcriptional regulatory domain and DAPIN/PAAD domain. IFI16 has three isotypes A, B, and C (85-95 kDa), which arise as a result of mRNA alternative splicing. All are phosphorylated on serine and threonine residues and can homo and heterodimerize. Expression is restricted to the nuclei of hematopoietic cells, fibroblasts and epithelial cells. IFI16 expression in hematopoietic cells of myeloid lineage is tightly regulated and highly induced in the differentiation and proliferation of the cell. Due to its localization in the nucleus, regulation of protein expression, and ability to bind DNA, it is assumed that IFI16 has a role in transcription regulation of cell differentiation. In addition, it was found that IFI16 can act as a transcriptional repressor and is involved in regulation and activation of p53 in cancer cells.

ID gène: 3428

Pathways: Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Autophagy, Inflammasome