Recombinant Aurora Kinase B anticorps (AA 89-251)

N° du produit ABIN6936445

Détail du produit anti-Aurora Kinase B anticorps

Antigène: Aurora Kinase B (AURKB)

Type d'anticorp: Recombinant Antibody

Épitope: AA 89-251

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Aurora Kinase B est non-conjugé

Application: Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificité: Recognizes a protein of 39 kDa, which is identified as Aurora B. The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant fragment (around aa 89-251) of human Aurora B protein (exact sequence is proprietary)

Clone: AURKB-3121R

Isotype: IgG

Information d'application

Indications d'application:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined.

Positive_Control: HeLa cells. Tonsil, Placenta, Hodgkin's Lymphoma or Colon Carcinoma.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur Aurora Kinase B

Antigène: Aurora Kinase B (AURKB)

Autre désignation: AURKB (AURKB Produits)

Synonymes: anticorps AIK2, anticorps AIM-1, anticorps AIM1, anticorps ARK2, anticorps AurB, anticorps IPL1, anticorps PPP1R48, anticorps STK12, anticorps STK5, anticorps aurkb-sv1, anticorps aurkb-sv2, anticorps AIRK2, anticorps AL022959, anticorps Aik2, anticorps Aim1, anticorps Ark2, anticorps STK-1, anticorps Stk12, anticorps Stk5, anticorps Aur B, anticorps Aurora B, anticorps Aurora-B, anticorps CG6620, anticorps DmAIRK2, anticorps DmAurB, anticorps DmAuroraB, anticorps Dmel\\CG6620, anticorps IAL, anticorps IAL1, anticorps Ial, anticorps aurB, anticorps aurora B, anticorps ARK-2, anticorps XAIRK2, anticorps aik2, anticorps aim-1, anticorps aim1, anticorps airk2, anticorps ark2, anticorps ipl1, anticorps stk12, anticorps stk5, anticorps CHUNP6896, anticorps fa09g06, anticorps stka, anticorps wu:fa09g06, anticorps aurkb, anticorps AIRK2-B, anticorps XAIRK2-B, anticorps aurkb-a, anticorps aurkb-b, anticorps xAurora-B-B, anticorps aurora kinase B, anticorps aurora B, anticorps aurora kinase B S homeolog, anticorps AURKB, anticorps Aurkb, anticorps aurB, anticorps aurkb, anticorps aurkb.S

Sujet: AIK2, AIM-1, ARK-2, AurB, AURKB, Aurora-1, Aurora and Ipl1 like midbody associated protein 1, Aurora kinase B, Aurora-B, Aurora-related kinase 2, Aurora/IPL1-related kinase 2, IPL1, Protein phosphatase 1 regulatory subunit 48 (PPP1R48), Serine/threonine-protein kinase 12, Serine/threonine-protein kinase aurora-B, STK1, STK12, STK5,Aurora B (Proliferation Marker)
Cellular localisation: Nuclear and Cytoplasmic

Poids moléculaire: 39kDa

ID gène: 9212, 442658

UniProt: Q96GD4

Pathways: TCR Signaling, Cycle Cellulaire, Maintenance of Protein Location, Hepatitis C, Toll-Like Receptors Cascades