Cyclin B2 anticorps

N° du produit ABIN6936587

Détail du produit anti-Cyclin B2 anticorps

Antigène: Cyclin B2 (CCNB2)

Reactivité: Xenopus laevis

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Cyclin B2 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Coating (Coat)

Specificité: In eukaryotic cells, mitosis is initiated following the activation of a protein kinase known variously as maturation-promoting factor, M phase specific histone kinase or M-phase kinase. This protein kinase is composed of a catalytic subunit (Cdc2), a regulatory subunit (cyclin B) and a low molecular weight subunit (p13-Suc1). The Cdc/cyclin enzyme is subject to multiple levels of control, of which the regulation of the catalytic subunit by tyrosine phosphorylation is the best understood. Tyrosine phosphorylation inhibits the Cdc2/ cyclin B enzyme, and tyrosine dephosphorylation, occurring at the onset of mitosis, directly activates the pre-MPF complex. Evidence has established that B type cyclins not only act on M phase regulatory subunits of the Cdc2 protein kinase, but also activate the Cdc25A and Cdc25B endogenous tyrosine phosphatase, of which Cdc2 is the physiological substrate. The two B type cyclins, cyclin B1 and cyclin B2, have been shown to have distinct tissue distributions.

Réactivité croisée (Details): Mouse. Rat. Human. Xenopus laevis.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant full-length Xenopus laevis Cyclin B2 protein

Clone: X29-2

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Known_Application: ELISA (For coating, order antibody without BSA), Optimal dilution for a specific application should be determined.

Positive_Control: HeLa cells. Human cervical tissue (IHC).

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur Cyclin B2

Antigène: Cyclin B2 (CCNB2)

Autre désignation: CCNB2 (CCNB2 Produits)

Synonymes: anticorps HsT17299, anticorps CycB2, anticorps sb:cb303, anticorps cycB2, anticorps LOC100136691, anticorps C-B2, anticorps cyclinb2, anticorps hst17299, anticorps LOC100282653, anticorps cyclin B2, anticorps cyclin B2 S homeolog, anticorps CCNB2, anticorps Ccnb2, anticorps ccnb2, anticorps LOC100136691, anticorps LOC100282653, anticorps ccnb2.S

Sujet: Ccnb2, CycB2, Cyclin B2, G2 mitotic specific cyclin B2, HsT17299, MGC108931, MGC140694,Cyclin B2
Cellular localisation: Cytoplasm.

Poids moléculaire: 51kDa

ID gène: 9133, 194698

UniProt: O95067

Pathways: Cycle Cellulaire, M Phase