CD4 anticorps

N° du produit ABIN6936703

Cet anticorps anti-CD4 Monoclonal Souris (Clone EDU-2) (ABIN6936703) détecte spécifiquement CD4 dans FACS, IF et Func. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour CD4 anticorps (ABIN6936703)

Antigène: CD4

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD4 est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Functional Studies (Func)

Clone: EDU-2

Détail du produit anti-CD4 anticorps

Specificité: Recognizes a protein of 55 kDa, identified as CD4. It is a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigens and is also a receptor for the human immunodeficiency virus. This protein is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.This MAb was characterized as human CD4 antibody at II and IV International Workshop on Human Leukocyte Differentiation Antigens.

Aucune reactivité croisée: Macaque rhésus

Réactivité croisée (Details): Human. Chimpanzee. Orangutan. Macaca artctoids (Stumptail monkey). Does not react with Macaca mulatta (Rhesus Monkey).

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Stimulated human leukocytes

Isotype: IgG2a kappa

Information d'application

Indications d'application:

Known_Application: Functional Studies (Order Ab without azide), Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Positive_Control: Human peripheral blood mononuclear cells (PBMCs), CCRF-CEM or HL-60. Lymph node or tonsil.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur CD4

Antigène: CD4

Autre désignation: CD4

Sujet: L3T4, Leu3, Ly-4, Lymphocyte antigen CD4, p55, T cell antigen T4/LEU3, T cell differentiation antigen L3T4, T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4,CD4 (T-Helper/Inducer Cell Marker)
Cellular localisation: Cell Surface

Poids moléculaire: 55kDa

ID gène: 920, 631659

UniProt: P01730

Pathways: TCR Signaling, Maintenance of Protein Location, CXCR4-mediated Signaling Events