Cadherin-16 anticorps

N° du produit ABIN6936885

L’anticorps anti-Cadherin-16 Polyclonal Lapin est utilisé pour la détection de Cadherin-16 dans des échantillons de Humain, Souris et Rat. Il a été validé pour IHC.

Aperçu rapide pour Cadherin-16 anticorps (ABIN6936885)

Antigène: Cadherin-16 (CDH16)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cadherin-16 est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-Cadherin-16 anticorps

Fonction: Ksp-Cadherin (Kidney-Specific Cadherin) / CDH16 Antibody

Specificité: This antibody recognizes a protein of 130 kDa, identified as Ksp-cadherin. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels.Ksp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma.

Réactivité croisée (Details): Human. Mouse. Rat.

Purification: 200ug/ml of Ab Purified by Protein A.

Immunogène: Recombinant human CDH16 protein

Isotype: IgG, kappa

Information d'application

Indications d'application:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: Normal kidney or renal cell carcinoma.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur Cadherin-16

Antigène: Cadherin-16 (CDH16)

Autre désignation: CDH16

Sujet:

Cadherin-16 (CDH16), Kidney-specific cadherin, Ksp-cadherin antibody

Normal kidney or renal cell carcinoma.

Poids moléculaire: 130kDa

ID gène: 1014, 513660

UniProt: O75309