Cadherin-16 anticorps (AA 371-507)

N° du produit ABIN6936887

Cet anticorps Souris Monoclonal détecte spécifiquement Cadherin-16 dans ELISA, IHC (f) et Coat. Il présente une réactivité envers Humain.

Aperçu rapide pour Cadherin-16 anticorps (AA 371-507) (ABIN6936887)

Antigène: Cadherin-16 (CDH16)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Cadherin-16 est non-conjugé

Application: ELISA, Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Coating (Coat)

Clone: CDH16-2448

Détail du produit anti-Cadherin-16 anticorps

Épitope: AA 371-507

Specificité: This MAb recognizes a protein of 130 kDa, identified as Ksp-cadherin. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels.Ksp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant fragment (around aa 371-507) of human CDH16 protein (exact sequence is proprietary)

Isotype: IgG2b kappa

Information d'application

Indications d'application:

Known_Application: ELISA (For coating, order Ab without BSA),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: Normal kidney or renal cell carcinoma.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur Cadherin-16

Antigène: Cadherin-16 (CDH16)

Autre désignation: CDH16

Sujet: Cadherin-16 (CDH16), Kidney-specific cadherin, Ksp-cadherin antibody,Ksp-Cadherin / CDH16 (Renal Cell Marker)
Cellular localisation: Cell Surface and Cytoplasmic

Poids moléculaire: 130kDa

ID gène: 1014, 513660

UniProt: O75309