Frataxin anticorps (AA 57-210)

N° du produit ABIN6937289

Cet anticorps Souris Monoclonal détecte spécifiquement Frataxin dans WB et IHC (f). Il présente une réactivité envers Humain.

Aperçu rapide pour Frataxin anticorps (AA 57-210) (ABIN6937289)

Antigène: Frataxin (FXN)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Frataxin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Clone: FXN-2124

Détail du produit anti-Frataxin anticorps

Épitope: AA 57-210

Specificité: Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), a human autosomal recessive neurodegenerative disease. Lack of Frataxin causes iron to accumulate in the mitochondrial matrix suggesting that Frataxin is involved in mitochondrial iron homeostasis and possibly in iron transport. Frataxin has an alpha-beta fold consisting of two helices flanking an antiparallel beta sheet.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant fragment of human Frataxin (FXN) protein (around aa 57-210) (exact sequence is proprietary)

Isotype: IgG2b kappa

Information d'application

Indications d'application:

Known_Application: Western Blot (1-2 μg/mL),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: HepG2, Panc-2, HL-60 or HEK293 cells. Pancreas and Liver.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur Frataxin

Antigène: Frataxin (FXN)

Autre désignation: FXN

Sujet: CyaY, d-FXN, FARR, Frataxin mature form, Frataxin (81-210), FRDA, Friedreich ataxia protein, Fxn, i-FXN, m56-FXN, m78-FXN, m81-FXN, X25,Frataxin (Marker of Friedreich Ataxia)
Cellular localisation: Cytoplasmic (Mitochondria)

Poids moléculaire: 14kDa

ID gène: 2395, 20685

UniProt: Q16595

Pathways: Transition Metal Ion Homeostasis, Regulation of Cell Size