JUP anticorps

N° du produit ABIN6937612

Cet anticorps anti-JUP est un anticorps Souris Monoclonal détectant JUP dans WB, IF et FACS. Adapté pour Humain.

Aperçu rapide pour JUP anticorps (ABIN6937612)

Antigène: JUP (Junction Plakoglobin (JUP))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp JUP est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: 1-10E05

Détail du produit anti-JUP anticorps

Specificité: It recognizes a protein of 80-87 kDa, identified as gamma-catenin. The catenins (, , and ) are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantly expressed in cardio-myocytes and in the peritubular myoid cells of the testis. T-catenin binds to E-catenin as well as to -catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for -T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimer s disease (LOAD) as well as to dilated cardiomyopathy.

Réactivité croisée (Details): Human. Mouse.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant full length human plakoglobin, fused to maltose binding protein

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Known_Application: Flow Cytometry (1-2 μg/million cells), ,Immunofluorescence (1-2 μg/mL), ,Western Blot (1-2 μg/mL),Optimal dilution for a specific application should be determined.

Positive_Control: HeLa, SK-BR3, HT20, A549, 293 or A431 cells. Skin.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur JUP

Antigène: JUP (Junction Plakoglobin (JUP))

Autre désignation: JUP

Sujet: ARVD12, Catenin (cadherin-associated protein), gamma 80 kDa, Catenin gamma, CTNNG, Desmoplakin III, Desmoplakin-3, DP3, DPIII, Junction Plakoglobin, PDGB, PKGB,Catenin, gamma (Cardiomyocyte Marker)
Cellular localisation: Cell Surface and Cytoplasmic

Poids moléculaire: 80-87kDa

ID gène: 3728, 514174

UniProt: P14923

Pathways: Cell-Cell Junction Organization, Maintenance of Protein Location