RAD51 anticorps (AA 1-134)

N° du produit ABIN6938308

Cet anticorps anti-RAD51 est un anticorps Souris Monoclonal détectant RAD51 dans WB, ELISA et Coat. Adapté pour Humain.

Aperçu rapide pour RAD51 anticorps (AA 1-134) (ABIN6938308)

Antigène: RAD51 (DNA Repair Protein Homolog 1 (RAD51))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp RAD51 est non-conjugé

Application: Western Blotting (WB), ELISA, Coating (Coat)

Clone: RAD51-2753

Détail du produit anti-RAD51 anticorps

Épitope: AA 1-134

Specificité: RAD51 is one of the key factors of DNA repair by homologous recombination and has been shown to have anti-apoptotic activity in tumor cells. RAD51 protein interacts with a variety of tumor suppressor proteins including p53, BRCA1 and BRCA2. Elevated expression of RAD51 enhances radio-resistance of human tumor cells. Overexpression of RAD51 protein in tumor cells renders them resistant against cytotoxic drugs like Cisplatin. RAD51 interacts with BRCA1 and BRCA2 to influence subcellular localization and cellular response to DNA damage. BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis from deregulation of RAD51. High-level expression of RAD51 has been observed in a variety of human malignancies.RAD51 overexpression correlates with histological grading of the tumor in invasive ductal mammary carcinoma.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant fragment of human RAD51 protein (around aa 1-134) (exact sequence is proprietary)

Isotype: IgG

Information d'application

Indications d'application:

Known_Application: ELISA (For coating, order Ab without BSA),Western Blot (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Positive_Control: HeLa or MCF-7 cells. Colon or breast Carcinoma.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur RAD51

Antigène: RAD51 (DNA Repair Protein Homolog 1 (RAD51))

Autre désignation: RAD51

Sujet: RCA1/BRCA2 containing complex, subunit 5, BRCC5, DNA repair protein RAD51, FANCR, HsT16930, MRMV2, RAD51, RAD51 recombinase, RAD51A, RECA, RecA like protein, Recombination protein A,RAD51 (Prognostic and Response to Chemotherapy Marker)
Cellular localisation: Nuclear

Poids moléculaire: 37kDa

ID gène: 5888, 631709

UniProt: Q06609

Pathways: Réparation de l'ADN