Recombinant Spectrin, Beta, Non-erythrocytic 2 (SPTBN2) (AA 356-475) anticorps

N° du produit ABIN6938443

Cet anticorps anti-Spectrin, Beta, Non-erythrocytic 2 Monoclonal Souris (Clone rSPTBN2-1778) (ABIN6938443) détecte spécifiquement Spectrin, Beta, Non-erythrocytic 2 dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant Spectrin, Beta, Non-erythrocytic 2 (SPTBN2) (AA 356-475) anticorps (ABIN6938443)

Antigène: Spectrin, Beta, Non-erythrocytic 2 (SPTBN2)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), ELISA

Clone: RSPTBN2-1778

Détail du produit

Épitope: AA 356-475

Fonction: Recombinant Spectrin beta III (SPTBN2) Antibody

Specificité: Spectrin is an actin binding protein that is a major component of the plasma membrane skeleton. Spectrins function as membrane organizers and stabilizers by forming dimers, tetramers and higher polymers. Vertebrate spectrins have two alpha-subunits (alpha-I/alpha-II) four beta-subunits (beta-I-beta-IV) and a beta-H subunit creating diversity and specialization of function. Spectrin and spectrin are present in erythrocytes, whereas spectrin II (also designated fodrin ) and spectrin I (also designated fodrin ) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Spectrin III is highly homologous to both spectrin I and spectrin II. Spectrin III is highly expressed in brain, kidney, pancreas and liver, and at lower levels in lung and placenta. Spectrin beta 3 is primarily expressed in nervous tissues with highest expression levels in the cerebellum, where it is found in Purkinje cell soma and dendrites.

Réactivité croisée (Details): Human.

Purification: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa356-475) of human SPTBN2 protein (exact sequence is proprietary)

Isotype: IgG1, kappa

Information d'application

Indications d'application:

Known_Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA), Western Blot (1-2 μg/mL),Optimal dilution for a specific application should be determined.

Positive_Control: PANC-1, HeLa or PC-3 cells. Human brain, pancreas or liver tissues (IHC).

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détail du antigène

Antigène: Spectrin, Beta, Non-erythrocytic 2 (SPTBN2)

Autre désignation: SPTBN2

Sujet:

Beta III spectrin, SCA5, Spectrin beta chain brain 2, Spectrin beta non-erythrocytic 2, Spectrin non-erythroid beta chain 2, Spinocerebellar ataxia 5, SPTBN2

HeLa or PC-3 cells. Human brain, PANC-1, pancreas or liver tissues (IHC). Human Kidney, Human Skin, HeLa or MCF7

Poids moléculaire: 246kDa

ID gène: 6712, 26915

UniProt: O15020

Pathways: Regulation of Actin Filament Polymerization, Synaptic Vesicle Exocytosis