VEGFR2/CD309 anticorps

N° du produit ABIN6938746

Cet anticorps anti-VEGFR2/CD309 Monoclonal Rat (Clone DC101) (ABIN6938746) détecte spécifiquement VEGFR2/CD309 dans WB. L’anticorps est réactif avec des échantillons de Souris.

Aperçu rapide pour VEGFR2/CD309 anticorps (ABIN6938746)

Antigène: VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp VEGFR2/CD309 est non-conjugé

Application: Western Blotting (WB)

Clone: DC101

Détail du produit anti-VEGFR2/CD309 anticorps

Fonction: VEGF-R2 / CD309 / Flk-1 / KDR3 Antibody

Specificité: This MAb is specific to Mouse VEGFR2/FLK-1/CD309 and does not cross-react with FLK-2. VEGFR2 is a type I transmembrane glycoprotein. It is a member of the CSF-1/PDGF receptor family of type III tyrosine kinase receptors. Endothelial cells, embryonic tissues, and megakaryocytes mainly express VEGFR2. It plays an important role in the regulation of angiogenesis, vasculogenesis, and vascular permeability. The ligands of VEGFR2 include VEGF-A, VEGF-C, VEGF-D, and VEGF splice isoforms. Ligation of VEGFR2 with its ligands results in the receptor dimerization and auto-phosphorylation, stimulating endothelial cell proliferation and migration.

Purification: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant full-length Mouse VEGFR2 protein

Isotype: IgG1, kappa

Information d'application

Indications d'application:

Positive Control: Mouse epidermoid, renal cell carcinoma, pancreatic or glioblastoma cells.

Known Application: Western Blot (Non-reducing) (2-5 μg/mL), Blocks Binding of VEGF to VEGF-R2 (Order Ab without BSA & Azide), Inhibits VEGF-induced Signaling (Order Ab without BSA & Azide), Blocks Tumor Growth in mice (Order Ab without BSA & Azide), Neutralizing, Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur VEGFR2/CD309

Antigène: VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))

Autre désignation: VEGFR2

Sujet:

CD309, Fetal liver kinase 1 (FLK-1), KDR, Kinase insert domain receptor (a type III receptor tyrosine kinase), KRD1, Ly73, Protein tyrosine kinase receptor FLK1, Vascular endothelial growth factor receptor 2

Mouse epidermoid, pancreatic or glioblastoma cells., renal cell carcinoma

Poids moléculaire: 180-190kDa

ID gène: 16542, 35918, 285

Pathways: Signalisation RTK, Glycosaminoglycan Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling