Neuregulin 1 anticorps (AA 21-242)

N° du produit ABIN6939613

Cet anticorps anti-Neuregulin 1 Monoclonal Souris (Clone NRG1-2710) (ABIN6939613) détecte spécifiquement Neuregulin 1 dans IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Neuregulin 1 anticorps (AA 21-242) (ABIN6939613)

Antigène: Neuregulin 1 (NRG1)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Neuregulin 1 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: NRG1-2710

Détail du produit anti-Neuregulin 1 anticorps

Épitope: AA 21-242

Fonction: Heregulin-1 / Neuregulin-1 (Breast and Urothelial Marker) Antibody

Specificité: Heregulin-1 is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD).

Purification: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment of human Neuregulin-1 (NRG1) protein (around aa 21-242) (exact sequence is proprietary)

Isotype: IgG1, kappa

Information d'application

Indications d'application:

Positive Control: A431, MCF-7 or T47D cells. Breast, Bladder or Thyroid Carcinoma.

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur Neuregulin 1

Antigène: Neuregulin 1 (NRG1)

Autre désignation: NRG1

Sujet:

Acetylcholine receptor-inducing activity (ARIA), Breast cancer cell differentiation factor p45, Glial growth factor (GGF2), Heregulin-1, Heregulin, alpha (45kD, ERBB2 p185-activator), HGL, HRG1, HRGA, MST131, Neu Differentiation Factor (NDF), Neuregulin-1, NRG1, Sensory and Motor Neuron-Derived Factor (SMDF)

A431, Bladder or Thyroid Carcinoma., MCF-7 or T47D cells. Breast

Poids moléculaire: 26-71kDa

ID gène: 3084, 453951, 668810

UniProt: Q02297

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation