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OGG1 anticorps

OGG1 Reactivité: Humain IHC, StM Hôte: Souris Monoclonal CPTC-OGG1-1 unconjugated
N° du produit ABIN6940242
  • Antigène Voir toutes OGG1 Anticorps
    OGG1 (8-Oxoguanine DNA Glycosylase (OGG1))
    Reactivité
    • 51
    • 25
    • 24
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 49
    • 4
    • 1
    Souris
    Clonalité
    • 44
    • 10
    Monoclonal
    Conjugué
    • 26
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp OGG1 est non-conjugé
    Application
    • 39
    • 14
    • 14
    • 13
    • 6
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Staining Methods (StM)
    Purification
    Purified by Protein A/G
    Immunogène
    Recombinant full-length human OGG1 protein
    Clone
    CPTC-OGG1-1
    Isotype
    IgG2c kappa
    Top Product
    Discover our top product OGG1 Anticorps primaire
  • Indications d'application

    Positive Control: HeLa or Jurkat cells. Kidney, skin or lymph node.

    Known Application: Immunohistochemistry (Formalin-fixed) (0.5-1 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-80 °C
    Stockage commentaire
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Date de péremption
    24 months
  • Antigène
    OGG1 (8-Oxoguanine DNA Glycosylase (OGG1))
    Autre désignation
    OGG1 (OGG1 Produits)
    Synonymes
    anticorps OGG1, anticorps zgc:158858, anticorps 8-oxoguanine-DNA glycosylase 1, anticorps ARABIDOPSIS 8-OXOGUANINE-DNA GLYCOSYLASE 1, anticorps ATOGG1, anticorps F8K7.14, anticorps F8K7_14, anticorps 19.m02329, anticorps DDBDRAFT_0184479, anticorps DDBDRAFT_0233024, anticorps DDB_0184479, anticorps DDB_0233024, anticorps ogg1, anticorps Tb04.1H19.930, anticorps HMMH, anticorps HOGG1, anticorps MUTM, anticorps OGH1, anticorps Mmh, anticorps 8-oxoguanine DNA glycosylase, anticorps 8-oxoguanine DNA glycosylase L homeolog, anticorps 8-oxoguanine-DNA glycosylase 1, anticorps 8-OXOGUANINE DNA GLYCOSYLASE, anticorps putative 8-oxoguanine DNA glycosylase, anticorps 8-oxoguanine DNA-glycosylase, anticorps N-glycosylase/DNA lyase OGG1, anticorps 8-oxoguanine DNA-glycosylase 1, anticorps OGG1, anticorps ogg1.L, anticorps ogg1, anticorps ECU08_0770, anticorps CA_C2707, anticorps BBOV_I004290, anticorps Smp_074010.1, anticorps LOC9329243, anticorps Tb927.4.2480, anticorps Ogg1
    Sujet
    8-oxoguanine (8-oxoG), an oxidized form of guanine, is produced by reactive oxygen species in both DNA and nucleotide pools during normal aging. Accumulation of 8-oxoG increases the occurrence of A:T to C:G or G:C to T:A transversionmutations, because 8-oxoG forms a stable basepair with adenine as well as with cytosine. OGG1 (for 8-oxoG DNA glycosylase), also designated MMH, is a DNA repair enzyme that corrects these mutations. Inactivation of the OGG1 gene leads to a mutator phenotype, characterized by the increase in G:C to T:A transversions. The OGG1 gene encodes eight isoforms (OGG1A-C, OGG2A-E) which result from alternative splicing of a single messenger RNA. The OGG1A splice variant is the most prevalent form and localizes to the nucleus, whereas the OGG2A splice variant is targeted to the mitochondria. Guanine is the main target for reactive oxygen species in DNA, and 8-oxoguanine is the most frequent base lesion. Therefore, formation of 8-oxoguanine is an important biomarker of oxidative damage to DNA. It is primarily repaired by the DNA glycosylase OGG1. Furthermore, defects in OGG1 may be a cause of renal cell carcinoma.
    Poids moléculaire
    39kDa
    ID gène
    4968
    UniProt
    O15527
    Pathways
    Réparation de l'ADN
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